3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

Base Information

Chemical Name:3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester
CAS No.:145691-02-7
Molecular Formula:C₂₃H₂₇N₃O₄S
Molecular Weight:441.551
Hs Code.:

Synonyms:3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

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Chemical Property of 3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

There total 8 articles about 3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56990-02-4
3,5-dibromobenzaldehyde

: 145691-02-7
3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / NaBH₄ / methanol / 0 - 20 °C

2: 94 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: Na₂CO₃ / acetone / 10 h / Heating

5: 81 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

6: 41 percent / aq. NaOH / ethanol / 0.75 h / Heating

7: 40 percent / diphenyl phosphorazidate, Et₃N / 18 h / Heating

8: 87 percent / TFA / CH₂Cl₂ / 4 h / Ambient temperature

9: 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.5 h / Ambient temperature

With dmap; palladium diacetate; sodium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; ammonium formate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone; acetonitrile;

Reference yield:

: 145691-59-4
(3,5-dibromophenyl)methanol

: 145691-02-7
3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: Na₂CO₃ / acetone / 10 h / Heating

4: 81 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

5: 41 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: 40 percent / diphenyl phosphorazidate, Et₃N / 18 h / Heating

7: 87 percent / TFA / CH₂Cl₂ / 4 h / Ambient temperature

8: 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.5 h / Ambient temperature

With dmap; palladium diacetate; sodium hydroxide; diphenyl phosphoryl azide; ammonium formate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone; acetonitrile;

Reference yield:

: (E)-3-[3-((E)-2-Ethoxycarbonyl-vinyl)-5-hydroxymethyl-phenyl]-acrylic acid ethyl ester

: 145691-02-7
3-[3-(2-Benzenesulfonylamino-ethyl)-5-imidazol-1-ylmethyl-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: Na₂CO₃ / acetone / 10 h / Heating

3: 81 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

4: 41 percent / aq. NaOH / ethanol / 0.75 h / Heating

5: 40 percent / diphenyl phosphorazidate, Et₃N / 18 h / Heating

6: 87 percent / TFA / CH₂Cl₂ / 4 h / Ambient temperature

7: 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.5 h / Ambient temperature

With dmap; sodium hydroxide; diphenyl phosphoryl azide; ammonium formate; sodium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone;