2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide

Base Information

• Chemical Name: 2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide
• CAS No.: 121217-51-4
• Molecular Formula: C₁₆H₁₁N₃O₃
• Molecular Weight: 293.282
• Mol file: 121217-51-4.mol

Synonyms:2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide

Chemical Property of 2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide

Chemical Property:

Purity/Quality:

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Technology Process of 2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide

There total 1 articles about 2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

cyanoacetanilide (621-03-4) + 2-nitro-benzaldehyde (552-89-6) → 2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide (121217-51-4)

Guidance literature:

With piperidine; In ethanol; for 1h; Heating;

DOI:10.1007/BF00633505

Reference yield: 85.0%

2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide (121217-51-4) → 2-aminoquinoline-3-carboxylic acid anilide (121217-60-5)

Guidance literature:

With iron; In acetic acid; for 7h; Heating;

DOI:10.1007/BF00633505

Reference yield:

2-cyano-3-(2-nitro-phenyl)-acrylic acid anilide (121217-51-4) → 2-acetamidoquinoline-3-carboxylic acid anilide (121217-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / iron filings / acetic acid / 7 h / Heating

2: 50 percent / pyridine / 0.5 h / 70 °C

With iron; In pyridine; acetic acid;

DOI:10.1007/BF00633505

upstream raw materials:

cyanoacetanilide

2-nitro-benzaldehyde

Downstream raw materials:

2-aminoquinoline-3-carboxylic acid anilide

2-acetamidoquinoline-3-carboxylic acid anilide

2-benzamidoquinoline-3-carboxylic acid anilide

Refernces