4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

Base Information

Chemical Name:4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine
CAS No.:1359951-16-8
Molecular Formula:C₂₈H₃₁F₂N₇O
Molecular Weight:519.597
Hs Code.:

Synonyms:4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

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Chemical Property of 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

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Technology Process of 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

There total 6 articles about 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-pyrrolidin-3-yl]pyrimidin-2-amine dihydrochloride

: 122-78-1
phenylacetaldehyde

: 1359951-16-8
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1240034-62-1
2-(difluoromethyl)-1-[2-(methylsulfanyl)-6-morpholin-4-ylpyrimidin-4-yl]-1H-benzimidazole

: 1359951-16-8
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / 0 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl acetamide / 1 h / 100 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1240034-64-3
2-(difluoromethyl)-1-[2-(methylsulfonyl)-6-morpholin-4-ylpyrimidin-4-yl]-1H-benzimidazole

: 1359951-16-8
4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-morpholin-4-yl-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl acetamide / 1 h / 100 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,4-dioxane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;