(R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

Base Information

Chemical Name:(R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate
CAS No.:750649-50-4
Molecular Formula:C₂₁H₂₀ClNO₃
Molecular Weight:369.848
Hs Code.:

Synonyms:(R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

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Chemical Property of (R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

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Technology Process of (R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

There total 2 articles about (R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 169221-13-0
(R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one

: 750649-50-4
(R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1016/j.tetasy.2004.05.021

Reference yield:

: 750649-46-8
(3R,3'R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

: 750649-50-4
(R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / NiCl₂*6H₂O / methanol / 0.5 h / 20 °C

2: 51 percent / DCC; DMAP / CH₂Cl₂ / 72 h / 20 °C

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide; nickel dichloride; In methanol; dichloromethane;
DOI:10.1016/j.tetasy.2004.05.021

Reference yield:

: 750649-50-4
(R)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 3-(4-chlorophenyl)-2-propenoate

: 169221-13-0
(R)-3-hydroxy-4,4-dimethyl-1-phenylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: CsF; BnEt₃NCl / toluene / 4 h / 20 °C

2: NaBH₄ / NiCl₂*6H₂O / methanol / 0.5 h / 20 °C

With sodium tetrahydroborate; N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; nickel dichloride; In methanol; toluene; 1: Michael addition;
DOI:10.1016/j.tetasy.2004.05.021