{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

Base Information

Chemical Name:{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester
CAS No.:357625-67-3
Molecular Formula:C₄₁H₄₉N₅O₈Si
Molecular Weight:767.954
Hs Code.:

{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1<i>H</i>-purin-2-yl}-carbamic acid allyl ester

Synonyms:{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

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Chemical Property of {9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

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Technology Process of {9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

There total 3 articles about {9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 357625-68-4
{9-[5-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

: 357625-67-3
{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; at 25 ℃; for 24h;
DOI:10.1081/NCN-100002082

Reference yield:

: 125138-91-2
N²-allyloxycarbonyl-2'-deoxyguanosine

: 357625-67-3
{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / imidazole / dimethylformamide / 24 h / 25 °C

2: 85 percent / DBU / pyridine / 24 h / 25 °C

With 1H-imidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; N,N-dimethyl-formamide;
DOI:10.1081/NCN-100002082

Reference yield:

: 102434-72-0
N²-<(allyloxy)carbonyl>-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 357625-67-3
{9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / TBAF / tetrahydrofuran / 24 h / 25 °C

2: 42 percent / imidazole / dimethylformamide / 24 h / 25 °C

3: 85 percent / DBU / pyridine / 24 h / 25 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1081/NCN-100002082