(R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

Base Information

Chemical Name:(R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one
CAS No.:211487-11-5
Molecular Formula:C₃₃H₅₀O₄Si
Molecular Weight:538.843
Hs Code.:

Synonyms:(R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

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Chemical Property of (R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

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Technology Process of (R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

There total 21 articles about (R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 211487-10-4
(E)-(S)-5-{(4S,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-4-methyl-hex-3-enoic acid methyl ester

: 211487-11-5
(R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

Guidance literature:: With dimethylsulfide; ozone;
DOI:10.1021/jo980982e

Reference yield:

: 187862-57-3
(2R,3S,6R)-3-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-octanal

: 211487-11-5
(R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / TiCl₄ / CH₂Cl₂ / 37 h / -78 - -20 °C

2.1: BCl₃*SMe₂ / CH₂Cl₂ / 16 h / -78 - -10 °C

3.1: p-TsOH / 8 h / 20 °C

4.1: O₃ / pyridine / methanol / -78 °C

4.2: 1.66 g / Me₂S / methanol / 12 h / -78 - 20 °C

With boron trichloride - methyl sulfide complex; titanium tetrachloride; ozone; pyridine; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo001767c

Reference yield:

: 211487-04-6
(E)-(5S,6S,7S,8S,11R)-8-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-4,5,7-trimethyl-tridec-3-enoic acid methyl ester

: 211487-11-5
(R)-3-{(4R,5R,6S)-6-[(R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-pentyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-butan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: BCl₃*SMe₂ / CH₂Cl₂ / 16 h / -78 - -10 °C

2.1: p-TsOH / 8 h / 20 °C

3.1: O₃ / pyridine / methanol / -78 °C

3.2: 1.66 g / Me₂S / methanol / 12 h / -78 - 20 °C

With boron trichloride - methyl sulfide complex; ozone; pyridine; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo001767c