N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

Base Information

Chemical Name:N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide
CAS No.:1018478-50-6
Molecular Formula:C₃₂H₄₇N₃O₆
Molecular Weight:569.742
Hs Code.:

N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

Synonyms:N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

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Chemical Property of N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

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Technology Process of N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

There total 9 articles about N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1018478-46-0
(3R,4R,5R)-3-aminomethyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidine-1-carboxylic acid benzyl ester

: 1865-01-6
(4-nitrophenyl) formate

: 1018478-50-6
N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

Guidance literature:: With triethylamine; In dichloromethane; for 60h; Inert atmosphere;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 1018478-50-6
N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; oil / 19 h / -10 - 20 °C

2: water; toluene-4-sulfonic acid / tetrahydrofuran; methanol / 15 h

3: borane-THF / tetrahydrofuran / 50 °C

4: triethylamine / dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

5: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 5 h / 45 °C / Inert atmosphere

6: ammonia; triphenylphosphine / tetrahydrofuran; methanol; water / 20 °C

7: triethylamine / dichloromethane / 60 h / Inert atmosphere

With sodium azide; borane-THF; ammonia; water; sodium hydride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; dmap; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; water; N,N-dimethyl-formamide; oil;

Reference yield:

: 1006865-82-2
(3S,4R,5R)-3-hydroxymethyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidine-1-carboxylic acid benzyl ester

: 1018478-50-6
N-{(3S,4R,5R)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidin-3-ylmethyl}-formamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 5 h / 45 °C / Inert atmosphere

3: ammonia; triphenylphosphine / tetrahydrofuran; methanol; water / 20 °C

4: triethylamine / dichloromethane / 60 h / Inert atmosphere

With sodium azide; ammonia; triethylamine; triphenylphosphine; dmap; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; water;