3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

Base Information

Chemical Name:3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one
CAS No.:1256916-24-1
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:

Synonyms:3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

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Chemical Property of 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

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Technology Process of 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

There total 3 articles about 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256916-83-2
4-[2-(2,5-dimethyl-phenyl)-acetoxy]-1-methoxy-piperidine-4-carboxylic acid ethyl ester

: 1256916-24-1
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 3.25h; Reflux; Inert atmosphere;

Reference yield:

: 102170-24-1
1-methoxypiperidin-4-one

: 1256916-24-1
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / dichloromethane / 20 - 28 °C / Inert atmosphere

2.1: hydrogenchloride / water / 2 h / 15 - 20 °C

2.2: 0 °C / pH 7

3.1: hydrogenchloride / -20 - 20 °C

3.2: pH ~ 5.5 / Cooling with ice

4.1: dmap; pyridine / 120 h / 0 - 20 °C / Inert atmosphere

5.1: potassium tert-butylate / tetrahydrofuran / 3.25 h / 0 °C / Reflux; Inert atmosphere

5.2: 0 °C / pH ~ 6

With pyridine; hydrogenchloride; dmap; potassium tert-butylate; zinc(II) chloride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1256917-10-8
1-methoxy-4-trimethylsilanyloxy-piperidine-4-carbonitrile

: 1256916-24-1
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-oxa-8-aza-spiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 2 h / 15 - 20 °C

1.2: 0 °C / pH 7

2.1: hydrogenchloride / -20 - 20 °C

2.2: pH ~ 5.5 / Cooling with ice

3.1: dmap; pyridine / 120 h / 0 - 20 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 3.25 h / 0 °C / Reflux; Inert atmosphere

4.2: 0 °C / pH ~ 6

With pyridine; hydrogenchloride; dmap; potassium tert-butylate; In tetrahydrofuran; water;