Technology Process of methyl N2,N2-bis(tert-butoxycarbonyl)-5-fluoro-L-lysinate 4-methylbenzenesulfonate
There total 7 articles about methyl N2,N2-bis(tert-butoxycarbonyl)-5-fluoro-L-lysinate 4-methylbenzenesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol; ethyl acetate;
for 5h;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap / dichloromethane / 20 °C
2.1: diisobutylaluminium hydride / diethyl ether; hexanes / 1.5 h / -78 - -70 °C
2.2: 0.67 h / 20 °C
3.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 0 - 20 °C
3.2: 1.5 h / 0 - 20 °C
4.1: triethylamine / dichloromethane / 1.17 h / 0 - 20 °C
5.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 5 h / 760.05 Torr
With
sodium azide; hydrogen; diisobutylaluminium hydride; N-fluorobis(benzenesulfon)imide; triethylamine; rac-Pro-OH;
dmap; palladium 10% on activated carbon;
In
tetrahydrofuran; hexanes; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / 12 - 20 °C
2.1: dmap / dichloromethane / 20 °C
3.1: diisobutylaluminium hydride / diethyl ether; hexanes / 1.5 h / -78 - -70 °C
3.2: 0.67 h / 20 °C
4.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 0 - 20 °C
4.2: 1.5 h / 0 - 20 °C
5.1: triethylamine / dichloromethane / 1.17 h / 0 - 20 °C
6.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C
7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 5 h / 760.05 Torr
With
thionyl chloride; sodium azide; hydrogen; diisobutylaluminium hydride; N-fluorobis(benzenesulfon)imide; triethylamine; rac-Pro-OH;
dmap; palladium 10% on activated carbon;
In
tetrahydrofuran; hexanes; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
