N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

Base Information

Chemical Name:N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn
CAS No.:694527-83-8
Molecular Formula:C₃₄H₅₇N₃O₇
Molecular Weight:619.842
Hs Code.:

Synonyms:N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

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Chemical Property of N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

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Technology Process of N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

There total 7 articles about N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 308279-65-4
(+)-(2R,3R)-3-hydroxy-2-methylnonanoic acid

: 694527-72-5
N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

: 694527-83-8
N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
Boc-L-aIle-OH

: 694527-83-8
N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / PyBOP; Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 3.00 g / HCl / ethyl acetate / 2 h / 20 °C

3: 96 percent / Et₃N; PyBOP / CH₂Cl₂ / 12 h / 0 - 20 °C

4: 93 percent / HCl / ethyl acetate / 1.3 h / 20 °C

5: 100 percent / Et₃N; diethylcyanophosphate / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; diethyl cyanophosphonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.055

Reference yield:

: 183793-47-7
(S)-2-tert-butoxycarbonylamino-3-methoxy-propionic acid benzyl ester

: 694527-83-8
N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Me)-OBn

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / HCl / ethyl acetate / 2 h / 20 °C

2: 95 percent / PyBOP; Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

3: 3.00 g / HCl / ethyl acetate / 2 h / 20 °C

4: 96 percent / Et₃N; PyBOP / CH₂Cl₂ / 12 h / 0 - 20 °C

5: 93 percent / HCl / ethyl acetate / 1.3 h / 20 °C

6: 100 percent / Et₃N; diethylcyanophosphate / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; diethyl cyanophosphonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmc.2003.10.055