N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

Base Information

Chemical Name:N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide
CAS No.:116005-74-4
Molecular Formula:C₂₁H₃₀N₄O₄
Molecular Weight:402.494
Hs Code.:

Synonyms:N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

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Chemical Property of N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

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Technology Process of N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

There total 4 articles about N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: (2-{2-Amino-5-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-benzylamino}-acetyl)-carbamic acid phenyl ester

: 116005-74-4
N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00119a015

Reference yield:

: 94193-38-1
N-Cyclohexyl-N-methyl-4-(3-formyl-4-nitrophenyl)-oxybutyramide

: 116005-74-4
N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / 1.) sodium acetate, 2.) sodium cyanoborohydride / 1.) methanol, reflux, 2.) room temperature, 3 h

2: triethylamine / tetrahydrofuran / 1 h / Ambient temperature

3: hydrogen / Pd-C / dimethylformamide / 3102.9 Torr

4: 24 percent / N,N-diisopropylethylamine, DMAP / tetrahydrofuran / Ambient temperature

With dmap; hydrogen; sodium acetate; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a015

Reference yield:

: 116005-70-0
N-cyclohexyl-N-methyl-4-<3-<<(carbamoylmethyl)amino>methyl>-4-nitrophenoxy>butyramide

: 116005-74-4
N-cyclohexyl-N-methyl-4-<<3-(carbamoylmethyl)-1,2,3,4-tetrahydro-2-oxoquinazolin-6-yl>oxy>butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / Ambient temperature

2: hydrogen / Pd-C / dimethylformamide / 3102.9 Torr

3: 24 percent / N,N-diisopropylethylamine, DMAP / tetrahydrofuran / Ambient temperature

With dmap; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a015