α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

Base Information

Chemical Name:α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile
CAS No.:157494-00-3
Molecular Formula:C₂₄H₂₉NO₂Si
Molecular Weight:391.585
Hs Code.:

Synonyms:α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

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Chemical Property of α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

Chemical Property:

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Technology Process of α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

There total 4 articles about α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3516-95-8
2'-hydroxy-3-phenylpropiophenone

: 157494-00-3
α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃ / acetone / 24 h / Heating

2: 84 percent / Na₂CO₃ / H₂O / 3 h / Heating

3: 88 percent / NaOAc, Ac₂O / 2 h / Heating

4: 95.6 percent / POCl₃ / 100 °C

5: 59 percent / ZnCl₂ / acetonitrile / 16 h

With sodium acetate; acetic anhydride; sodium carbonate; potassium carbonate; zinc(II) chloride; trichlorophosphate; In water; acetone; acetonitrile;

Reference yield:

: 91401-72-8
2-(ω-phenyl-propionyl)-phenoxy-acetic acid

: 157494-00-3
α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / NaOAc, Ac₂O / 2 h / Heating

2: 95.6 percent / POCl₃ / 100 °C

3: 59 percent / ZnCl₂ / acetonitrile / 16 h

With sodium acetate; acetic anhydride; zinc(II) chloride; trichlorophosphate; In acetonitrile;

Reference yield:

: 157493-96-4
2-(2-(3-phenylpropionyl)-phenoxy)-essigsaeureethylester

: 157494-00-3
α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / Na₂CO₃ / H₂O / 3 h / Heating

2: 88 percent / NaOAc, Ac₂O / 2 h / Heating

3: 95.6 percent / POCl₃ / 100 °C

4: 59 percent / ZnCl₂ / acetonitrile / 16 h

With sodium acetate; acetic anhydride; sodium carbonate; zinc(II) chloride; trichlorophosphate; In water; acetonitrile;