ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

Base Information

Chemical Name:ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate
CAS No.:1196490-97-7
Molecular Formula:C₁₉H₂₄N₄O₆S
Molecular Weight:436.489
Hs Code.:

Synonyms:ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

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Chemical Property of ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

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Technology Process of ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

There total 3 articles about ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1196490-93-3
ethyl (3aS,4R,5R,7aR)-2,2-dimethyl-8-[(4-methylphenyl)-sulfonyl]-3a,4,5,7a-tetrahydro-4,5-epimino-1,3-benzodioxole-7-carboxylate

: 1196490-97-7
ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo2018872

Reference yield:

: 1173701-22-8
(+)-ethyl (5S,6R)-5,6-dihydroxycyclohexa-1,3-dienecarboxylate

: 1196490-97-7
ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

2: copper acetylacetonate / acetonitrile / 5 h / 0 °C / Inert atmosphere

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

With copper acetylacetonate; sodium azide; ammonium chloride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo2018872

Reference yield:

: 1185040-54-3
(+)-ethyl (3aR,7aS)-2,2-dimethyl-3a,7a-dihydrobenzo[d][1,3]dioxole-4-carboxylate

: 1196490-97-7
ethyl (3aR,6S,7R,7aS)-6-azido-2,2-dimethyl-7-{[(4-methylphenyl)sulfonyl]amino}-3a,6,7,7a-tetrahydro-1,3-benzodioxole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper acetylacetonate / acetonitrile / 5 h / 0 °C / Inert atmosphere

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

With copper acetylacetonate; sodium azide; ammonium chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo2018872