(1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

Base Information

Chemical Name:(1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde
CAS No.:178379-73-2
Molecular Formula:C₁₈H₃₀O₂
Molecular Weight:278.435
Hs Code.:

Synonyms:(1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

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Chemical Property of (1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

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Technology Process of (1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

There total 4 articles about (1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 392234-98-9
(1S,3aS,5R,7aR)-1-hydroxymethyl-5-cyclohexylmethyl-7a-methylperhydroinden-3a-ol

: 178379-73-2
(1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; for 1h;
DOI:10.1021/jm011001k

Reference yield:

: 1S,3aS,7aR-1-hydroxymethyl-5-benzyl-7a-methylperhydroinden-3a-ol

: 178379-73-2
(1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 32 percent / imidazole / dimethylformamide / 16 h / 20 °C

2: 83 percent / H₂ / 5percent Rh/Al₂O₃ / methanol / 3 h / 3268.22 Torr

3: 100 percent / aq. HCl / dioxane / 2 h

4: 83 percent / IBX / dimethylsulfoxide / 1 h

With 1H-imidazole; hydrogenchloride; hydrogen; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; 5percent Rh/Al₂O₃; In 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm011001k

Reference yield:

: (1S,3aS,7aR)-1-hydroxymethyl-5-benzyliden-7a-methylperhydroinden-3a-ol

: 178379-73-2
(1S,3aS,5R,7aR)-3a-hydroxy-5-cyclohexylmethyl-7a-methylperhydroindene-1-carboxaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h / atmospheric pressure

2: 32 percent / imidazole / dimethylformamide / 16 h / 20 °C

3: 83 percent / H₂ / 5percent Rh/Al₂O₃ / methanol / 3 h / 3268.22 Torr

4: 100 percent / aq. HCl / dioxane / 2 h

5: 83 percent / IBX / dimethylsulfoxide / 1 h

With 1H-imidazole; hydrogenchloride; hydrogen; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; 10percent Pd/C; 5percent Rh/Al₂O₃; In 1,4-dioxane; methanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm011001k