(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

Base Information

Chemical Name:(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane
CAS No.:235108-11-9
Molecular Formula:C₂₆H₄₄O₄SSi
Molecular Weight:480.784
Hs Code.:

Synonyms:(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

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Chemical Property of (8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

Chemical Property:

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Technology Process of (8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

There total 6 articles about (8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 235107-97-8
(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-(hydroxymethyl)pregnane

: 98-59-9
p-toluenesulfonyl chloride

: 235108-11-9
(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

Guidance literature:: With pyridine; at -20 - 4 ℃;

Reference yield:

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 235108-11-9
(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / -20 - 0 °C

2: 2,6-dimethylpyridine / dichloromethane / 0.25 h / 0 °C

3: sodium hydrogencarbonate; dimethyl sulfoxide / 1.25 h / 120 °C

4: tetra(n-butyl)ammonium hydroxide / dichloromethane; water / 20 h / 18 °C

5: sodium tetrahydroborate / dichloromethane; ethanol / 0.75 h

6: pyridine / -20 - 4 °C

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; tetra(n-butyl)ammonium hydroxide; sodium hydrogencarbonate; dimethyl sulfoxide; In ethanol; dichloromethane; water; 3: Kornblum oxidation;

Reference yield:

: 186372-30-5
(1R,3aR,4S,7aR)-octahydro-1-[(1’S)-1’-methyl-2’-oxo-ethanyl]-7a-methyl-4-triethylsilyloxy-1H-indene

: 235108-11-9
(8S,20R)-des-A,B-8-[(triethylsilyl)oxy]-20-[(p-toluenesulfonyl)oxy]methyl-pregnane

Guidance literature:: Multi-step reaction with 3 steps

1: tetra(n-butyl)ammonium hydroxide / dichloromethane; water / 20 h / 18 °C

2: sodium tetrahydroborate / dichloromethane; ethanol / 0.75 h

3: pyridine / -20 - 4 °C

With pyridine; sodium tetrahydroborate; tetra(n-butyl)ammonium hydroxide; In ethanol; dichloromethane; water;