(S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

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Chemical Name:(S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)
CAS No.:1381963-25-2
Molecular Formula:C₅₈H₇₄F₂N₁₀O₆
Molecular Weight:1045.29
Hs Code.:

Synonyms:(S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

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Chemical Property of (S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

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Technology Process of (S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

There total 3 articles about (S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1381963-38-7
C₆₈H₉₀F₂N₁₀O₁₀

: 1381963-25-2
(S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

Guidance literature:: C₆₈H₉₀F₂N₁₀O₁₀; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere; Cooling with ice bath;

In methanol; dichloromethane;

Reference yield:

: 872460-12-3
5-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1381963-25-2
(S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 3 h / 80 °C / Inert atmosphere

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice bath

2.2: 4 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere; Cooling with ice bath

3.2: PL-HC₀₃ MP SPE columns

With sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1020176-96-8
((S)-1-{(S)-2-[(S)-2-(5-Bromo-pyridin-3-yl)-pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester

: 1381963-25-2
(S,S,S)-N,N'-(ethane-1,2-diyl)bis(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorobenzamide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 3 h / 80 °C / Inert atmosphere

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice bath

2.2: 4 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere; Cooling with ice bath

3.2: PL-HC₀₃ MP SPE columns

With sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;