1-[1-(2-Fluorophenyl)-2-(trimethylsilyl)ethyl]cyclohexanol

Base Information

• Chemical Name: 1-[1-(2-Fluorophenyl)-2-(trimethylsilyl)ethyl]cyclohexanol
• CAS No.: 106795-67-9
• Molecular Formula: C₁₇H₂₇FOSi
• Molecular Weight: 294.485
• DSSTox Substance ID: DTXSID301192798
• Mol file: 106795-67-9.mol

Synonyms:1-[1-(2-Fluorophenyl)-2-(trimethylsilyl)ethyl]cyclohexanol;DTXSID301192798;106795-67-9

Chemical Property of 1-[1-(2-Fluorophenyl)-2-(trimethylsilyl)ethyl]cyclohexanol

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 294.18152018
• Heavy Atom Count: 20
• Complexity: 307

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[Si](C)(C)CC(C1=CC=CC=C1F)C2(CCCCC2)O

Technology Process of 1-[1-(2-Fluorophenyl)-2-(trimethylsilyl)ethyl]cyclohexanol

There total 5 articles about 1-[1-(2-Fluorophenyl)-2-(trimethylsilyl)ethyl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(trimethylsilyl)methylmagnesium chloride (13170-43-9) + 2-(o-fluorophenyl)-1-oxaspiro<2,5>octane (106795-61-3) → 1-cyclohexan-1-ol (106795-67-9)

Guidance literature:

With copper(l) chloride; In tetrahydrofuran; at 35 ℃; for 22h;

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-cyclohexan-1-ol (106795-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / sodium ethoxide / ethanol / 0.5 h / Heating

2: 89 percent / m-chloroperbenzoic acid / CHCl₃ / 3.5 h / 0 °C

3: 72 percent / copper (I) chloride / tetrahydrofuran / 22 h / 35 °C

With sodium ethanolate; 3-chloro-benzenecarboperoxoic acid; copper(l) chloride; In tetrahydrofuran; ethanol; chloroform;

Reference yield:

2-fluorobenzyl chloride (345-35-7) → 1-cyclohexan-1-ol (106795-67-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / toluene / 16 h / Heating

2: 66 percent / sodium ethoxide / ethanol / 0.5 h / Heating

3: 89 percent / m-chloroperbenzoic acid / CHCl₃ / 3.5 h / 0 °C

4: 72 percent / copper (I) chloride / tetrahydrofuran / 22 h / 35 °C

With sodium ethanolate; 3-chloro-benzenecarboperoxoic acid; copper(l) chloride; In tetrahydrofuran; ethanol; chloroform; toluene;

upstream raw materials:

(trimethylsilyl)methylmagnesium chloride

2-(o-fluorophenyl)-1-oxaspiro<2,5>octane

cyclohexanone

2-fluorobenzyl chloride

Downstream raw materials:

1-fluoro-2-(1-vinylcyclohexyl)benzene