tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

Base Information

Chemical Name:tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate
CAS No.:1582272-15-8
Molecular Formula:C₁₈H₂₃ClN₂O₂
Molecular Weight:334.846
Hs Code.:

Synonyms:tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

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Chemical Property of tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

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Technology Process of tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

There total 3 articles about tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: tert-butyl 3-(4-ethoxy-2,4-dioxobutyl)-2-((ethoxycarbonothioyl)thio)azetidine-1-carboxylate

: 89-97-4
2-CHLOROBENZYLAMINE

: 1582272-14-7
tert-butyl ethyl 2-(4-(((tert-butoxycarbonyl)amino)methyl)-1-(2-chlorobenzyl)-1H-pyrrol-2-yl)acetate

: 1582272-15-8
tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol500544u

Reference yield:

: 141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate

: 1582272-15-8
tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 24 h / 0 °C / Cooling

2.1: potassium tert-butylate / tert-butyl alcohol / 80 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / ethyl acetate / 0.25 h / Reflux

3.2: Reflux

4.1: toluene-4-sulfonic acid / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; potassium tert-butylate; toluene-4-sulfonic acid; In 1,4-dioxane; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ol500544u

Reference yield:

: 605655-08-1
tert-butyl 3-{[(4-methylphenyl)sulfonyl]oxy}azetidine-1-carboxylate

: 1582272-15-8
tert-butyl ((1-(2-chlorobenzyl)-5-methyl-1H-pyrrol-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 80 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / ethyl acetate / 0.25 h / Reflux

2.2: Reflux

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

With 2,6-dimethylpyridine; potassium tert-butylate; toluene-4-sulfonic acid; In 1,4-dioxane; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/ol500544u