N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide

Base Information

• Chemical Name: N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide
• CAS No.: 891849-25-5
• Molecular Formula: C₄₀H₃₇F₃N₆O₄
• Molecular Weight: 722.767
• Mol file: 891849-25-5.mol

Synonyms:N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide

Chemical Property of N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide

There total 7 articles about N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(4-amino-benzyl)-10-isobutyl-7-trifluoromethyl-10H-benzo[g]pteridine-2,4-dione (891849-35-7) + N-(2,2-diphenyl-ethyl)-succinamic acid pentafluorophenyl ester → N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide (891849-25-5)

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/ol060620q

Reference yield:

N1-isobutyl-4-(trifluoromethyl)benzene-1,2-diamine (908369-02-8) → N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide (891849-25-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 25 percent / boron oxide; acetic acid / 3 h / 80 °C

2: 24 percent / potassium carbonate / dimethylformamide / 6 h / 90 °C

3: 45 percent / ammonium formate / Pd/C / methanol; acetone / 1 h / 20 °C

4: 86 percent / 4-dimethylaminopyridine / dimethylformamide / 12 h / 20 °C

With dmap; boron trioxide; ammonium formate; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol060620q

Reference yield:

N-isobutyl-2-nitro-4-(trifluoromethyl)aniline (891849-41-5) → N-(2,2-diphenyl-ethyl)-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide (891849-25-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / ammonium formate / Pd on carbon / methanol / 2 h / 20 °C

2: 25 percent / boron oxide; acetic acid / 3 h / 80 °C

3: 24 percent / potassium carbonate / dimethylformamide / 6 h / 90 °C

4: 45 percent / ammonium formate / Pd/C / methanol; acetone / 1 h / 20 °C

5: 86 percent / 4-dimethylaminopyridine / dimethylformamide / 12 h / 20 °C

With dmap; boron trioxide; ammonium formate; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol060620q

upstream raw materials:

3-(4-amino-benzyl)-10-isobutyl-7-trifluoromethyl-10H-benzo[g]pteridine-2,4-dione

N¹-isobutyl-4-(trifluoromethyl)benzene-1,2-diamine

N-isobutyl-2-nitro-4-(trifluoromethyl)aniline

7-trifluoromethyl-10-isobutyl flavin