(1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

Base Information

• Chemical Name: (1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol
• CAS No.: 104154-97-4
• Molecular Formula: C₁₇H₂₄O₂
• Molecular Weight: 260.376
• Mol file: 104154-97-4.mol

Synonyms:(1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

Chemical Property of (1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

There total 5 articles about (1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-endo-3-endo camphane-2,3-diol (73522-22-2) + benzyl chloride (100-44-7) → (+)-(1R,2R,3S,4S)-2-benzyloxy-3-hydroxy-1,7,7-trimethylbicyclo<2.2.1>heptane (73440-85-4,89015-58-7,104154-98-5,110312-07-7,110312-08-8) + (1R,2R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol (104154-97-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

Reference yield: 30.0%

dioxa-3,5 exo phenyl-4 syn trimethyl-7,10,10 tricyclo <5.2.1.02,6> decane (88969-71-5,89016-00-2) → (1R,2S,3R,4S)-3-Benzyloxy-4,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol (73440-85-4,89015-58-7,104154-98-5,110312-07-7,110312-08-8) + (1S,2R,3S,4R)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol (73440-88-7,89015-59-8,104154-97-4)

Guidance literature:

With diisobutylaluminium hydride; In toluene; for 1h; Ambient temperature;

DOI:10.1246/cl.1983.1593

Reference yield: 9.0%

(1S,2R,6S,7R)-1,10,10-Trimethyl-4-phenyl-3,5-dioxa-tricyclo[5.2.1.02,6]decane (88969-71-5,89016-00-2) → (1R,2S,3R,4S)-3-Benzyloxy-4,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol (73440-85-4,89015-58-7,104154-98-5,110312-07-7,110312-08-8) + (1S,2R,3S,4R)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol (73440-88-7,89015-59-8,104154-97-4)

Guidance literature:

With diisobutylaluminium hydride; In toluene; for 0.1h; Ambient temperature;

DOI:10.1246/cl.1983.1593

upstream raw materials:

2-endo-3-endo camphane-2,3-diol

benzyl chloride

dioxa-3,5 exo phenyl-4 syn trimethyl-7,10,10 tricyclo <5.2.1.0^2,6> decane

(1S,2R,6S,7R)-1,10,10-Trimethyl-4-phenyl-3,5-dioxa-tricyclo[5.2.1.0^2,6]decane

Downstream raw materials:

(1R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one