Fmoc-His(3-Me)-OH

Base Information

Chemical Name:Fmoc-His(3-Me)-OH
CAS No.:252049-16-4
Molecular Formula:C₂₂H₂₁N₃O₄
Molecular Weight:391.426
Hs Code.:2933 29 90
European Community (EC) Number:802-233-0
Mol file:252049-16-4.mol

Synonyms:Fmoc-His(3-Me)-OH;252049-16-4;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-methylimidazol-4-yl)propanoic Acid;(2S)-2-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO}-3-(3-METHYLIMIDAZOL-4-YL)PROPANOIC ACID;SCHEMBL15729186;Fmoc-His(3-Me)-OH, AldrichCPR;AKOS027251076;FD21693;HY-W111226;AS-49162;PD171710;CS-0169358;EN300-3405084;Na-(((9H-Fluoren-9-yl)methoxy)carbonyl)-Np-methyl-L-histidine;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1-methyl-1H-imidazol-5-yl)propanoic acid

Suppliers and Price of Fmoc-His(3-Me)-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Fmoc-3-methyl-L-histidine Novabiochem?
250 mg
$ 130.00

Sigma-Aldrich
Fmoc-3-methyl-L-histidine Novabiochem . CAS 252049-16-4, molar mass 391.42 g/mol., Novabiochem
8522868250
$ 126.00

Sigma-Aldrich
Fmoc-3-methyl-L-histidine Novabiochem?
1 g
$ 388.00

Sigma-Aldrich
Fmoc-3-methyl-L-histidine Novabiochem . CAS 252049-16-4, molar mass 391.42 g/mol., Novabiochem
8522860001
$ 375.00

Iris Biotech GmbH
Fmoc-L-His(3-Me)-OH
1 g
$ 506.25

Iris Biotech GmbH
Fmoc-L-His(3-Me)-OH
5 g
$ 1991.25

Crysdot
Fmoc-His(3-Me)-OH 95+%
1g
$ 441.00

Crysdot
Fmoc-His(3-Me)-OH 95+%
250mg
$ 183.00

Chem-Impex
Fmoc-His(3-Me)-OH ≥ 99% (HPLC)
5G
$ 1290.00

Chem-Impex
Fmoc-His(3-Me)-OH,99%(HPLC) 99%(HPLC)
250MG
$ 145.60

Total 16 raw suppliers

Chemical Property of Fmoc-His(3-Me)-OH

Chemical Property:

Boiling Point:686.7±55.0 °C(Predicted)
PKA:3.46±0.10(Predicted)
PSA：93.45000
Density:1.34±0.1 g/cm3(Predicted)
LogP:3.34540
Storage Temp.:-15°C
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:391.15320616
Heavy Atom Count:29
Complexity:579

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-3-methyl-L-histidine Novabiochem? ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=NC=C1CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Isomeric SMILES:CN1C=NC=C1C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of Fmoc-His(3-Me)-OH

There total 4 articles about Fmoc-His(3-Me)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₃N₃O₄

: 252049-16-4
Fmoc-L-His(N3-Me)-OH

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; for 0.0833333h;
DOI:10.7717/peerj.3429

Reference yield:

: 109425-51-6
Fmoc-His(Trt)-OH

: 252049-16-4
Fmoc-L-His(N3-Me)-OH

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / 20 °C

2.1: trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -75 °C / Inert atmosphere

2.2: -75 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 4 h / 20 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran / 0.08 h

With thionyl chloride; lithium hydroxide monohydrate; chlorotriisopropylsilane; trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.7717/peerj.3429

Reference yield:

: 937801-67-7
methyl-N^α-(((9H-fluoren-9-yl)methoxy)carbonyl)-N^τ-trityl-L-histidinate

: 252049-16-4
Fmoc-L-His(N3-Me)-OH

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -75 °C / Inert atmosphere

1.2: -75 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane / 4 h / 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran / 0.08 h

With lithium hydroxide monohydrate; chlorotriisopropylsilane; trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.7717/peerj.3429