PIPERIDIN-1-YL-ACETIC ACID

Base Information

• Chemical Name: PIPERIDIN-1-YL-ACETIC ACID
• CAS No.: 3235-67-4
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 2933399090
• Mol file: 3235-67-4.mol

Synonyms:2-Piperidin-1-ylaceticacid;N-Carboxymethylpiperidine;Piperidin-1-ylacetic acid;Piperidine-1-ylacetic acid;Piperidinoacetic acid;

Chemical Property of PIPERIDIN-1-YL-ACETIC ACID

Chemical Property:

• Melting Point: 214-216 °C(Solv: chloroform (67-66-3))
• Boiling Point: 252.2 °C at 760 mmHg
• PKA: 2.47±0.10(Predicted)
• Flash Point: 106.3 °C
• PSA: 40.54000
• Density: 1.103 g/cm³
• LogP: 0.49480

Purity/Quality:

97% ^*data from raw suppliers

2-(Piperidin-1-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDIN-1-YL-ACETIC ACID

There total 12 articles about PIPERIDIN-1-YL-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

piperidin-1-yl-acetic acid ethyl ester (23853-10-3) → piperidinoacetic acid (3235-67-4,478920-86-4)

Guidance literature:

With hydrogenchloride; In water; at 95 ℃; for 16h;

Reference yield: 93.0%

tert-butyl 2-(piperidin-1-yl)acetate (924281-69-6) → piperidinoacetic acid (3235-67-4,478920-86-4)

Guidance literature:

In water; isopropyl alcohol; at 160 ℃; for 0.333333h; Flow reactor;

DOI:10.1016/j.bmc.2017.03.020

Reference yield: 89.0%

piperidine (110-89-4) + bromoacetic acid (79-08-3) → piperidinoacetic acid (3235-67-4,478920-86-4)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 72h; pH=14;

DOI:10.1016/j.bmc.2004.10.004

upstream raw materials:

piperidine

chloroacetic acid

piperidin-1-yl-acetic acid ethyl ester

bromoacetic acid

Downstream raw materials:

N-Piperidinessigsaeure-butylester

dibenzyl piperidinoglycyl-L-prolyl-L-glutamate

N-(1-piperidinomethylcarbonyl)-L-phenylalanine

N-(4-Acetyl-phenyl)-2-piperidin-1-yl-acetamide