methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

Base Information

Chemical Name:methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]
CAS No.:769955-22-8
Molecular Formula:C₂₇H₃₂O₄
Molecular Weight:420.549
Hs Code.:

Synonyms:methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

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Chemical Property of methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

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Technology Process of methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

There total 3 articles about methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 769956-93-6
(8R,9S,13S,14S)-methyl 3-(benzyloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-17-oxo-6H-cyclopenta[a]phenanthrene-16-carboxylate

: 769955-22-8
methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

: 769955-23-9
JAC₀₁₀₁₃B

Guidance literature:: (8R,9S,13S,14S)-methyl 3-(benzyloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-17-oxo-6H-cyclopenta[a]phenanthrene-16-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 769956-93-6
(8R,9S,13S,14S)-methyl 3-(benzyloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-17-oxo-6H-cyclopenta[a]phenanthrene-16-carboxylate

: 769955-22-8
methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

: 438536-55-1
16β-hydroxymethyl-3-benzyloxyestra-1,3,5(10)-trien-17β-ol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 18h;
DOI:10.1021/jm050830t

Reference yield:

: 858-98-0
3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

: 769955-22-8
methyl [(17β)-3-(benzyloxy)-17-hydroxyestra-1,3,5(10)-triene-16-carboxylate]

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / Heating

1.2: 81 percent / tetrahydrofuran / 8 h / Heating

2.1: NaBH₄ / tetrahydrofuran; ethanol / 18 h / 0 - 20 °C

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/jm050830t