6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

Base Information

Chemical Name:6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid
CAS No.:1411982-72-3
Molecular Formula:C₂₄H₂₇FN₄O₄S
Molecular Weight:486.567
Hs Code.:

Synonyms:6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

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Chemical Property of 6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

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Technology Process of 6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

There total 8 articles about 6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411982-80-3
methyl 6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonyl-amino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylate

: 1411982-72-3
6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

Guidance literature:: methyl 6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonyl-amino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylate; With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 110 ℃; for 0.75h; microwave irradiation;

With formic acid; In 1,4-dioxane; methanol; water; pH=4 - 5;

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1411982-72-3
6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 24 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 2 h / 95 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.75 h / 110 °C / microwave irradiation

3.2: pH 4 - 5

With pyridine; lithium hydroxide monohydrate; water; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 90050-54-7
methyl 6-amino-3-bromo-2-nitrobenzoate

: 1411982-72-3
6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 3 h / 20 °C

2.1: potassium carbonate; N,N`-dimethylethylenediamine / copper(l) iodide / toluene / 5 h / 110 °C / Cooling with ice

3.1: acetic acid; iron / 2.5 h / 115 °C

4.1: sulfuric acid / methanol / 44 h / Reflux

5.1: pyridine / dichloromethane / 24 h / 20 °C

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 2 h / 95 °C / Inert atmosphere

7.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.75 h / 110 °C / microwave irradiation

7.2: pH 4 - 5

With pyridine; lithium hydroxide monohydrate; sulfuric acid; water; iron; potassium carbonate; acetic acid; N,N`-dimethylethylenediamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; di-tert-butylneopentylphosphonium tetrafluoroborate; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; toluene;