1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one

Base Information

• Chemical Name: 1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one
• CAS No.: 118267-01-9
• Molecular Formula: C₂₀H₂₀O₄
• Molecular Weight: 324.376

Synonyms:1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one

Chemical Property of 1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one

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Technology Process of 1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one

There total 7 articles about 1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

buroussochalcone B (28448-85-3) → 1-(7-hydroxy-2,2-dimethylchroman-6-yl)-3-(4-hydroxyphenyl)propenone (118267-01-9)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.tetlet.2007.08.124

Reference yield: 80.0%

broussochalcone B → 1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one (118267-01-9)

Guidance literature:

With polyphosphoric acid; air; In N,N-dimethyl-formamide; at 110 ℃; for 2h; regioselective reaction;

DOI:10.1080/00397911.2021.1902537

Reference yield:

1-(7-hydroxy-2,2-dimethylchroman-6-yl)ethanone (31273-58-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 1-[7-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl]-3-(4-hydroxyphenyl)-2-propen-1-one (118267-01-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 96h;

upstream raw materials:

1-(7-hydroxy-2,2-dimethylchroman-6-yl)ethanone

4-hydroxy-benzaldehyde

buroussochalcone B

2',4'-dihydroxy-4-acetophenone

Downstream raw materials:

8-[3-(3-methyl-2-butenyl)-4-hydroxyphenyl]-2,2-dimethyl-3,4,7,8-tetrahydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one

8-(4-hydroxyphenyl)-2,2-dimethyl-3,4,7,8-tetrahydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one

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