(R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

Base Information

Chemical Name:(R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine
CAS No.:1133854-27-9
Molecular Formula:C₁₄H₁₂F₃N₃
Molecular Weight:279.265
Hs Code.:

Synonyms:(R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

Chemical Property:

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Technology Process of (R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

There total 5 articles about (R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.8%

: 1133853-72-1
5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

: 1133854-27-9
(R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

Guidance literature:: With chiral column; Resolution of racemate;
DOI:10.1021/jm401955h

Reference yield:

: 54-96-6
3,4-diaminopyridine

: 1133854-27-9
(R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol; water / 2 h / Reflux

2.1: magnesium; iodine / tetrahydrofuran / 2 h / Reflux

2.2: 2.33 h / 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C

4.1: trimethylsilyl iodide / chloroform / 7.5 h / 70 °C

5.1: chiral column / Resolution of racemate

With trimethylsilyl iodide; palladium 10% on activated carbon; hydrogen; iodine; magnesium; In tetrahydrofuran; ethanol; chloroform; water;
DOI:10.1021/jm401955h

Reference yield:

: 1133853-70-9
ethyl 5-(4-(trifluoromethyl)phenyl)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate

: 1133854-27-9
(R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl iodide / chloroform / 7.5 h / 70 °C

2: chiral column / Resolution of racemate

With trimethylsilyl iodide; In chloroform;
DOI:10.1021/jm401955h