(S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

Base Information

Chemical Name:(S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide
CAS No.:1371595-84-4
Molecular Formula:C₂₃H₁₉FN₄O₃
Molecular Weight:418.427
Hs Code.:

Synonyms:(S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

Suppliers and Price of (S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

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Chemical Property of (S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

There total 3 articles about (S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1371596-31-4
C₂₀H₁₂ClFN₂O

: 65414-74-6
L-serinamide hydrochloride

: 1371595-84-4
(S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

Guidance literature:: With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

Reference yield:

: 607-68-1
2,4-dichloroquinazoline

: 1371595-84-4
(S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 18 h / 95 °C / Inert atmosphere

2: potassium carbonate; triethylamine / N,N-dimethyl-formamide / 24 h / 100 °C

With potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 361437-00-5
(4-(4-fluorophenoxy)phenyl)boronic acid

: 1371595-84-4
(S)-2-{4-[4-(4-fluoro-phenoxy)-phenyl]-quinazolin-2-ylamino}-3-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 18 h / 95 °C / Inert atmosphere

2: potassium carbonate; triethylamine / N,N-dimethyl-formamide / 24 h / 100 °C

With potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; toluene;