7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

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Chemical Name:7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one
CAS No.:281225-29-4
Molecular Formula:C₂₄H₁₆ClN₃O₃S
Molecular Weight:461.928
Hs Code.:

7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-4-one

Synonyms:7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

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Chemical Property of 7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

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Technology Process of 7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

There total 3 articles about 7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 2284-20-0
4-Methoxyphenyl isothiocyanate

: 190319-69-8
2-amino-6-(4-chloro-phenyl)-4-furan-2-yl-nicotinamide

: 281225-29-4
7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:: In diphenylether; for 9h; Heating;
DOI:10.1080/10426509808033729

Reference yield:

: 77607-70-6
2-amino-3-cyano-6-p-chlorophenyl-4-(2'-furyl)-pyridine

: 281225-29-4
7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: ethanolic KOH / 22 h / Heating

2: 81 percent / diphenyl ether / 9 h / Heating

With potassium hydroxide; In diphenylether; 1: Hydrolysis / 2: Cyclization;
DOI:10.1080/10426509808033729

Reference yield:

: 14385-65-0,114570-70-6
1-(4-chlorophenyl)-3-(furan-2-yl)-2-propen-1-one

: 281225-29-4
7-(4-chloro-phenyl)-5-furan-2-yl-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: CH₃COONH₄ / ethanol / 22 h / Heating

2: ethanolic KOH / 22 h / Heating

3: 81 percent / diphenyl ether / 9 h / Heating

With potassium hydroxide; ammonium acetate; In diphenylether; ethanol; 1: Condensation / 2: Hydrolysis / 3: Cyclization;
DOI:10.1080/10426509808033729