N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine

Base Information

• Chemical Name: N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine
• CAS No.: 853306-07-7
• Molecular Formula: C₁₂H₁₃F₆N
• Molecular Weight: 285.232
• Mol file: 853306-07-7.mol

Synonyms:N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine

Chemical Property of N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine

Chemical Property:

Purity/Quality:

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Technology Process of N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine

There total 1 articles about N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{N-{1-(3,5-bistrifluoromethyl)phenyl-1-methyl}ethyl}-N-methylformamide (853306-06-6) → N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine (853306-07-7)

Guidance literature:

{N-{1-(3,5-bistrifluoromethyl)phenyl-1-methyl}ethyl}-N-methylformamide; With water; hydrogen bromide; In ethanol; at 20 - 60 ℃;

With sodium hydrogencarbonate; In ethanol; water; at 0 ℃;

Reference yield:

N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine (853306-07-7) → (3S,4S)-1-benzyloxycarbonyl-4-[N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methyl]aminocarbonyl-3-(4-fluoro-2-methylphenyl)piperidine

Guidance literature:

(3S,4S)-1-benzyloxycarbonyl-4-carboxyl-3-(4-fluoro-2-methyl-phenyl)piperidine; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 16h;

N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 48h;

Reference yield:

N-{1-(3,5-bistrifluoromethylphenyl)-1-methylethyl}-N-methylamine (853306-07-7) + 1,1'-carbonyldiimidazole (530-62-1) → C16H15F6N3O

Guidance literature:

In tetrahydrofuran; for 0.333333 - 16h; Heating / reflux;

upstream raw materials:

{N-{1-(3,5-bistrifluoromethyl)phenyl-1-methyl}ethyl}-N-methylformamide