2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

Base Information

Chemical Name:2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine
CAS No.:1599478-77-9
Molecular Formula:C₁₉H₂₆ClF₃N₂O
Molecular Weight:390.876
Hs Code.:

Synonyms:2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

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Chemical Property of 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

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Technology Process of 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

There total 9 articles about 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599479-17-0
C₁₉H₂₄ClF₃N₄O

: 1599478-77-9
2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1599478-96-2
benzyl 9-(2-methoxy-2-oxoethylidene)-3-azaspiro[5.5]undec-7-ene-3-carboxylate

: 1599478-77-9
2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

Guidance literature:: Multi-step reaction with 8 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 35 - 40 °C / 2585.81 Torr

2: methanol; hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate / 1,4-dioxane / 36 h / 100 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

5: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 1 h / -10 °C / Inert atmosphere

7: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

8: water; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; borane-THF; 15-crown-5; palladium 10% on activated carbon; water; hydrogen; caesium carbonate; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1599478-77-9
2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)ethanamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium tert-butylate / tert-butyl methyl ether; isopropyl alcohol / 2 h / 10 - 30 °C

2.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 - 30 °C / Inert atmosphere

2.2: 40 - 50 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 35 - 40 °C / 2585.81 Torr

4.1: methanol; hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate / 1,4-dioxane / 36 h / 100 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

7.1: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 1 h / -10 °C / Inert atmosphere

9.1: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

10.1: water; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; borane-THF; 15-crown-5; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; isopropyl alcohol;