(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

Base Information

Chemical Name:(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate
CAS No.:1623012-92-9
Molecular Formula:C₄₅H₇₃N₁₁O₁₀
Molecular Weight:928.142
Hs Code.:

(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

Synonyms:(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

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Chemical Property of (S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

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Technology Process of (S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

There total 7 articles about (S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1623012-91-8
(S)-20-(benzyloxycarbonylamino)-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

: 1623012-92-9
(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: methyl 4-((6-amino-8-bromo-2-(butylamino)-9H-purin-9-yl)methyl)benzoate

: 1623012-92-9
(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; methanol / 18 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: methyl 4-((6-amino-2-(butylamino)-9H-purin-9-yl)methyl)benzoate

: 1623012-92-9
(S)-20-amino-9,14-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,19-dioxo-3-oxa-5,9,14,18-tetraazahenicosan-21-yl-4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / chloroform / 18 h / 20 °C

2: sodium hydroxide / water; methanol / 18 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; bromine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;