(1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one

Base Information

• Chemical Name: (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one
• CAS No.: 93965-76-5
• Molecular Formula: C₁₇H₁₈ClNO₂
• Molecular Weight: 303.788

Synonyms:(1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one

Chemical Property of (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Useful:

Technology Process of (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one

There total 4 articles about (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetyl-5-methylfuran (1193-79-9) → (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-en-4-one (93965-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaCN*BH₃, HCl / methanol

2: Et₃N / CH₂Cl₂

3: toluene / 1.1 h / 110 °C

With hydrogenchloride; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/ja00338a071

Reference yield:

Benzyl-[1-(5-methyl-furan-2-yl)-ethyl]-amine (1019609-07-4) → (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-en-4-one (93965-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: toluene / 1.1 h / 110 °C

With triethylamine; In dichloromethane; toluene;

DOI:10.1021/ja00338a071

Reference yield:

benzylamine (100-46-9) → (1S,2R,5R,6R,7R)-3-Benzyl-6-chloro-2,7-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-en-4-one (93965-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaCN*BH₃, HCl / methanol

2: Et₃N / CH₂Cl₂

3: toluene / 1.1 h / 110 °C

With hydrogenchloride; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/ja00338a071

upstream raw materials:

2-acetyl-5-methylfuran

Benzyl-[1-(5-methyl-furan-2-yl)-ethyl]-amine

benzylamine

Downstream raw materials:

Acetic acid (1S,3R,4R,7R,8S,9R,10R)-5-benzyl-10-chloro-9-iodo-1,4-dimethyl-6-oxo-2-oxa-5-aza-tricyclo[5.2.1.0^3,8]dec-3-yl ester

(3S,6S,7S,7aS)-2-Benzyl-7-chloro-6-hydroxy-3,6-dimethyl-2,3,7,7a-tetrahydro-6H-[2]pyrindine-1,4-dione

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