Technology Process of C37H53NO8Si
There total 5 articles about C37H53NO8Si which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4S)-3-[1-oxo-2-(4-methoxybenzyloxy)ethyl]-4-benzyl-2-oxazolidinone;
With
di-n-butylboryl trifluoromethanesulfonate; triethylamine;
In
dichloromethane; toluene;
at -50 ℃;
for 1h;
Inert atmosphere;
(2S,6R)-2-(2-tert-butyldimethylsilyloxy-1,1-dimethylethyl)-6-(2-oxoethyl)-2,3-dihydro-6H-pyran;
In
dichloromethane; toluene;
at -50 - -30 ℃;
for 2.5h;
Inert atmosphere;
In
dichloromethane; toluene;
optical yield given as %de;
aq. phosphate buffer;
DOI:10.1016/j.tet.2011.09.131
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane / 0.75 h / -23 °C / Inert atmosphere
2.2: 20 °C
3.1: boron trifluoride diethyl etherate / acetonitrile / 3.5 h / 20 °C / Inert atmosphere
4.1: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane; toluene / 1 h / -50 °C / Inert atmosphere
4.2: 2.5 h / -50 - -30 °C / Inert atmosphere
4.3: aq. phosphate buffer
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; diisobutylaluminium hydride; triethylamine;
In
dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2011.09.131
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / dichloromethane / 0.75 h / -23 °C / Inert atmosphere
1.2: 20 °C
2.1: boron trifluoride diethyl etherate / acetonitrile / 3.5 h / 20 °C / Inert atmosphere
3.1: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane; toluene / 1 h / -50 °C / Inert atmosphere
3.2: 2.5 h / -50 - -30 °C / Inert atmosphere
3.3: aq. phosphate buffer
With
di-n-butylboryl trifluoromethanesulfonate; boron trifluoride diethyl etherate; diisobutylaluminium hydride; triethylamine;
In
dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2011.09.131
