N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

Base Information

Chemical Name:N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide
CAS No.:57963-17-4
Molecular Formula:C₂₆H₁₆Cl₂N₄O₂
Molecular Weight:487.345
Hs Code.:

Synonyms:N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

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Chemical Property of N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

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Technology Process of N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

There total 9 articles about N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 61807-88-3
N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

: 57963-17-4
N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

Guidance literature:: With sulfuric acid; for 18h; Ambient temperature;
DOI:10.1021/jo00321a010

Reference yield:

: 1775-18-4
N-(2-methyl-[1,3]dioxolan-2-ylmethyl)-phthalimide

: 57963-17-4
N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / Br₂ / ethane-1,2-diol / Heating

2: 95 percent / NaN₃ / dimethylsulfoxide / 100 h / 100 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 2585.7 Torr / Ambient temperature

4: 84 percent / ethanol / 18 h / 60 °C

5: 74 percent / conc. H₂SO₄ / 18 h / Ambient temperature

With sodium azide; sulfuric acid; hydrogen; bromine; palladium on activated charcoal; In ethanol; ethylene glycol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00321a010

Reference yield:

: 57963-12-9
(3-phthalimidoacetonyl)bromide, ethylene ketal

: 57963-17-4
N-<<8-chloro-6-(o-chlorophenyl)-4H-imidazo<1,2-a><1,4>benzodiazepin-1-yl>methyl>phthalimide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaN₃ / dimethylsulfoxide / 100 h / 100 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 2585.7 Torr / Ambient temperature

3: 84 percent / ethanol / 18 h / 60 °C

4: 74 percent / conc. H₂SO₄ / 18 h / Ambient temperature

With sodium azide; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00321a010