(E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Base Information

Chemical Name:(E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
CAS No.:1394248-65-7
Molecular Formula:C₂₅H₂₇FN₈
Molecular Weight:458.541
Hs Code.:

Synonyms:(E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

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Chemical Property of (E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

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Technology Process of (E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

There total 6 articles about (E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1249715-13-6
N-4-fluorobenzyl-2-imidazolealdehyde

: 1394248-34-0
C₁₄H₂₀N₆

: 1394248-65-7
(E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Guidance literature:: Reflux;
DOI:10.1016/j.ejmech.2012.05.039

Reference yield:

: 607-68-1
2,4-dichloroquinazoline

: 1394248-65-7
(E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.25 h / 30 °C

2: hydrazine hydrate / ethanol / 1 h / 80 - 100 °C

3: Reflux

With hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.ejmech.2012.05.039

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1394248-65-7
(E)-2-(2-((1-(4-fluorobenzyl)-1H-imidazol-2-yl)methylene)hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 12 h / 160 °C

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 6 h / 90 °C

3: triethylamine / tetrahydrofuran / 0.25 h / 30 °C

4: hydrazine hydrate / ethanol / 1 h / 80 - 100 °C

5: Reflux

With hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.ejmech.2012.05.039