1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Base Information

Chemical Name:1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea
CAS No.:1229439-25-1
Molecular Formula:C₂₃H₁₈Cl₂N₆O₃
Molecular Weight:497.34
Hs Code.:

Synonyms:1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Suppliers and Price of 1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

There total 11 articles about 1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1229439-22-8
1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-methoxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

: 1229439-25-1
1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Guidance literature:: With boron tribromide-dimethyl sulfide complex; In 1,2-dichloro-ethane; Reflux;

Reference yield:

: 50720-12-2
3-bromo-5-methoxypyridine

: 1229439-25-1
1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 80 °C / Schlenk technique; Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Schlenk technique; Inert atmosphere

3: boron tribromide dimethyl sulfide complex / 1,2-dichloro-ethane / 10 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; boron tribromide dimethyl sulfide complex; In 1,4-dioxane; dimethyl sulfoxide; 1,2-dichloro-ethane; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00829

Reference yield:

: C₁₃H₁₀BrN₃O₂

: 1229439-25-1
1-(3,5-dichloropyridin-4-yl)-3-(2-ethyl-6-(3-(5-hydroxypyridin-3-yl)phenyl)-3-oxo-2,3-dihydropyridazin-4-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 2.5 h

1.2: 20 °C

2.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Schlenk technique; Inert atmosphere

3.1: boron tribromide dimethyl sulfide complex / 1,2-dichloro-ethane / 10 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; caesium carbonate; boron tribromide dimethyl sulfide complex; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00829