(4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Base Information

Chemical Name:(4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol
CAS No.:50640-77-2
Molecular Formula:C₁₆H₂₃NO
Molecular Weight:245.365
Hs Code.:

Synonyms:(4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Suppliers and Price of (4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

There total 20 articles about (4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 97523-21-2
(4aS,8aS)-6-Oxo-4a-phenyl-octahydro-isoquinoline-2-carboxylic acid ethyl ester

: 50640-77-2
(4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo00219a006

Reference yield:

: 17605-06-0
ethyl 3-oxohept-6-enoate

: 50640-77-2
(4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Guidance literature:: Multi-step reaction with 12 steps

1: NaBH₄ / propan-2-ol / 0.5 h / 0 °C

2: pyridine / 2 h / 80 °C

3: 72 percent / 1,7-diazabicyclo<5.4.0>undec-7-ene (DBU) / benzene / 2 h / Heating

4: 94 percent / CuI / diethyl ether / 1.5 h / 0 °C

5: 75 percent / NaOH / ethanol / 2 h / Heating

6: Et₃N, ClCOOMe, NaN₃ / acetone / 1.5 h / Ambient temperature

7: toluene / 3 h / Heating

8: 88 percent / sodium formate / 3 h / Ambient temperature

9: 95 percent / formic acid / 1.5 h / Ambient temperature

10: 95 percent / 3N aq. NaOH / ethanol / 0.5 h / Ambient temperature

11: 85 percent / CrO₃, H₂SO₄ / acetone / 0.17 h / 0 °C

12: 81 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

With pyridine; chromium(VI) oxide; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; sodium azide; sulfuric acid; sodium formate; triethylamine; methyl chloroformate; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In tetrahydrofuran; diethyl ether; ethanol; isopropyl alcohol; acetone; toluene; benzene;
DOI:10.1021/jo00219a006

Reference yield:

: 87046-26-2
((Z)-3-Phenyl-octa-3,7-dienyl)-carbamic acid ethyl ester

: 50640-77-2
(4aS,6R,8aS)-2-Methyl-4a-phenyl-decahydro-isoquinolin-6-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / sodium formate / 3 h / Ambient temperature

2: 95 percent / formic acid / 1.5 h / Ambient temperature

3: 95 percent / 3N aq. NaOH / ethanol / 0.5 h / Ambient temperature

4: 85 percent / CrO₃, H₂SO₄ / acetone / 0.17 h / 0 °C

5: 81 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

With chromium(VI) oxide; sodium hydroxide; lithium aluminium tetrahydride; formic acid; sulfuric acid; sodium formate; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jo00219a006