(E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

Base Information

Chemical Name:(E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne
CAS No.:1430717-69-3
Molecular Formula:C₁₉H₂₂F₃IO
Molecular Weight:450.283
Hs Code.:

Synonyms:(E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

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Chemical Property of (E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

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Technology Process of (E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

There total 4 articles about (E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 693-03-8
n-butyl magnesium bromide

: 1430717-67-1
6-benzyloxy-1,1,1-trifluoro-6-methyl-2,4-heptadiyne

: 1430717-69-3
(E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

Guidance literature:: n-butyl magnesium bromide; With copper(l) cyanide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

6-benzyloxy-1,1,1-trifluoro-6-methyl-2,4-heptadiyne; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With iodine; In tetrahydrofuran; for 1h; Inert atmosphere;
DOI:10.3762/bjoc.8.249

Reference yield: 54.0%

: 109-72-8,29786-93-4
n-butyllithium

: 1430717-67-1
6-benzyloxy-1,1,1-trifluoro-6-methyl-2,4-heptadiyne

: 1430717-69-3
(E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

Guidance literature:: n-butyllithium; With copper(l) cyanide; In tetrahydrofuran; hexane; at -45 - -20 ℃; Inert atmosphere;

6-benzyloxy-1,1,1-trifluoro-6-methyl-2,4-heptadiyne; In tetrahydrofuran; hexane; at -45 ℃; for 1h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; for 1h; stereoselective reaction; Inert atmosphere;
DOI:10.3762/bjoc.8.249

Reference yield:

: 50420-73-0
3-(benzyloxy)-3-methylbut-1-yne

: 1430717-69-3
(E)-6-benzyloxy-3-n-butyl-1,1,1-trifluoro-2-iodo-6-methyl-2-hepten-4-yne

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.1: copper(l) cyanide / tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

3.3: 1 h / Inert atmosphere

With copper(l) iodide; palladium diacetate; copper(l) cyanide; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: |Sonogashira Cross-Coupling;
DOI:10.3762/bjoc.8.249