5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

Base Information

Chemical Name:5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine
CAS No.:1430073-63-4
Molecular Formula:C₃₄H₃₈N₂O₈SSi
Molecular Weight:662.836
Hs Code.:

Synonyms:5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

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Technology Process of 5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

There total 2 articles about 5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1430073-62-3
5'-O-p-toluenesulfonyl-2'-O,4'-C-methylenethymidine

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1430073-63-4
5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1080/15257770.2013.783218

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 206055-67-6
(1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

: 1430073-63-4
5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 8 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1080/15257770.2013.783218

Reference yield: 82.0%

: 1430073-63-4
5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine

: 623-51-8
ethyl 2-sulfanylacetate

: 1430073-64-5
ethyl 2-S-(3'-O-tert-butyldiphenylsilyl-5'-deoxy-2'-O,4'-C-methylenethymidin-5'-yl)mercaptoacetate

Guidance literature:: ethyl 2-sulfanylacetate; With sodium hydride; In hexane; N,N-dimethyl-formamide; for 0.5h;

5'-O-p-toluenesulfonyl-3'-O-tert-butyldiphenylsilyl-2'-O,4'-C-methylenethymidine; In hexane; N,N-dimethyl-d₆-formamide; at 0 - 20 ℃; for 1h;
DOI:10.1080/15257770.2013.783218