2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 358387-80-1
• Molecular Formula: C₁₅H₁₁F₃N₂O
• Molecular Weight: 292.26
• Mol file: 358387-80-1.mol

Synonyms:2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 1 articles about 2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

3-Trifluoromethylbenzaldehyde (454-89-7) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one (358387-80-1)

Guidance literature:

With tin(ll) chloride; In ethanol; at 120 ℃; for 0.333333h; Microwave irradiation; Green chemistry;

DOI:10.1071/CH20101

Reference yield:

2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one (358387-80-1) → C16H10F3N5 (1448068-49-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium permanganate / N,N-dimethyl-formamide / Reflux

2: Lawessons reagent / toluene / Reflux

3: hydrazine hydrate / methanol / 12 h / Reflux

4: sodium carbonate / water; 1,4-dioxane / 12 h / 10 °C

With Lawessons reagent; potassium permanganate; sodium carbonate; hydrazine hydrate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;

DOI:10.1002/ardp.201200376

Reference yield:

2-(3-(trifluoromethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one (358387-80-1) → 2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one (138867-15-9)

Guidance literature:

With potassium permanganate; In N,N-dimethyl-formamide; Reflux;

DOI:10.1002/ardp.201200376

upstream raw materials:

3-Trifluoromethylbenzaldehyde

anthranilic acid amide

Downstream raw materials:

C₁₆H₁₀F₃N₅

2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one

C₁₅H₉F₃N₂S

C₁₅H₁₁F₃N₄