Cyclobutanecarboxylic acid, 2-formyl-1-methyl-, methyl ester, (1R,2R)-rel- (9CI)

Base Information

Chemical Name:Cyclobutanecarboxylic acid, 2-formyl-1-methyl-, methyl ester, (1R,2R)-rel- (9CI)
CAS No.:249930-46-9
Molecular Formula:C₈H₁₂O₃
Molecular Weight:156.181
Hs Code.:
Mol file:249930-46-9.mol

Synonyms:Cyclobutanecarboxylic acid, 2-formyl-1-methyl-, methyl ester, (1R,2R)-rel- (9CI)

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Chemical Property of Cyclobutanecarboxylic acid, 2-formyl-1-methyl-, methyl ester, (1R,2R)-rel- (9CI)

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Technology Process of Cyclobutanecarboxylic acid, 2-formyl-1-methyl-, methyl ester, (1R,2R)-rel- (9CI)

There total 8 articles about Cyclobutanecarboxylic acid, 2-formyl-1-methyl-, methyl ester, (1R,2R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: methyl 2-(hydroxymethyl)-1-methylcyclobutane-1-carboxylate

: 249930-46-9
methyl 2-formyl-1-methylcyclobutanecarboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: (1S,2S)-2-Hydroxymethyl-1-methyl-cyclobutanecarboxylic acid methyl ester

: (1S,2R)-2-Formyl-1-methyl-cyclobutanecarboxylic acid methyl ester

: 249930-46-9
(1S,2S)-2-Formyl-1-methyl-cyclobutanecarboxylic acid methyl ester

Guidance literature:: With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane; at 0 - 25 ℃; for 2h;
DOI:10.1039/a905019a

Reference yield:

: 80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7
methacrylic acid methyl ester

: 249930-46-9
(1S,2S)-2-Formyl-1-methyl-cyclobutanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / TiCl₄ / CH₂Cl₂ / 96 h / 40 °C

2: 87 percent / BF₃*2AcOH / CH₂Cl₂ / 4 h / 40 °C

3: 51 percent / KF; NaHCO₃; H₂O₂ / methanol; tetrahydrofuran / 24 h / 25 °C

4: TPAP; NMO; molecular sieves 4 Angstroem / CH₂Cl₂ / 2 h / 0 - 25 °C

With potassium fluoride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; dihydrogen peroxide; boron trifluoride diacetate; titanium tetrachloride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; 1: Cycloaddition / 2: Substitution / 3: Oxidation / 4: Oxidation;
DOI:10.1039/a905019a