4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate

Base Information

• Chemical Name: 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate
• CAS No.: 88816-47-1
• Molecular Formula: C₂₅H₃₃ClN₂O₈S₂Si
• Molecular Weight: 617.216
• Mol file: 88816-47-1.mol

Synonyms:4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate

Chemical Property of 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate

There total 2 articles about 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzyl 3,3-di-(acetylthio)-2-[(3S,4R)-4-allylthio-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate (83378-66-9) → 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate (88816-47-1)

Guidance literature:

With chlorine; In tetrachloromethane;

Reference yield:

4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-ethylthio-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate (88816-45-9) → 4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate (88816-47-1)

Guidance literature:

With chlorine; In chloroform; at 20 ℃; Yield given;

DOI:10.1039/c39830001006

Reference yield: 90.0%

4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-chloro-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate (88816-47-1) → (5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester (80926-64-3)

Guidance literature:

With 1H-imidazole; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1039/c39830001006

upstream raw materials:

4-Nitrobenzyl 3,3-di(acetylthio)-2-[(3S,4R)-4-ethylthio-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate

4-nitrobenzyl 3,3-di-(acetylthio)-2-[(3S,4R)-4-allylthio-3-(1'(R)-{dimethyl-{2-methylprop-2-yl}silyloxy}ethyl)-2-azetidinon-1-yl]propenoate

Downstream raw materials:

(5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester