3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

Base Information

Chemical Name:3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine
CAS No.:138840-78-5
Molecular Formula:C₃₁H₃₅N₃O₄SSi
Molecular Weight:573.788
Hs Code.:

Synonyms:3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

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Chemical Property of 3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

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Technology Process of 3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

There total 3 articles about 3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 15922-79-9
O-Acetyl N-hydroxy-2-thiopyridone

: 138840-75-2
5'-Anisyltelluro-3'-O-tert.-butyldiphenylsilyl-5'-deoxy-thymidine

: 138840-78-5
3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

: 138840-76-3
3'-O-tert.-Butyldiphenylsilyl-5'-deoxy-5'-(2-thiopyridyl)-thymidine

Guidance literature:: In dichloromethane; at 40 ℃; Irradiation;
DOI:10.1016/S0040-4020(01)80885-1

Reference yield:

: 83467-48-5
1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 138840-78-5
3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / pyridine / Ambient temperature

2: 98 percent / NaBH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 80 percent / CH₂Cl₂ / 40 °C / Irradiation

With pyridine; sodium tetrahydroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)80885-1

Reference yield:

: 138840-74-1
3'-O-tert-Butyldiphenylsilyl-5'-O-methanesulfonyl-thymidine

: 138840-78-5
3'-O-tert-Butyldiphenylsilyl-5',6'-cyclo-5'-deoxy-5-(2-thiopyridyl)-5,6-dihydrothymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NaBH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 80 percent / CH₂Cl₂ / 40 °C / Irradiation

With sodium tetrahydroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)80885-1