(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate
CAS No.:1572937-32-6
Molecular Formula:C₁₇H₂₂N₂O₇
Molecular Weight:366.371
Hs Code.:

Synonyms:(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

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Technology Process of (2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

There total 1 articles about (2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 554-84-7
meta-nitrophenol

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1572937-32-6
(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.07.079

Reference yield: 98.0%

: 1572937-32-6
(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

: 1572937-33-7
(2S,4R)-tert-butyl 2-(hydroxymethyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

Guidance literature:: With lithium borohydride; In tetrahydrofuran;

Reference yield:

: 1572937-32-6
(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

: 1572937-41-7
C₂₃H₂₉FN₂O₄

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

3: hydrazine hydrate / methanol

With lithium borohydride; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; methanol; 2: |Mitsunobu Displacement;