(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

Base Information

Chemical Name:(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone
CAS No.:1138328-15-0
Molecular Formula:C₂₄H₂₅F₆NO₆S₂
Molecular Weight:601.588
Hs Code.:

Synonyms:(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

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Chemical Property of (4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

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Technology Process of (4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

There total 6 articles about (4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidine hydrochloride

: 4-(methylsulfonyl)-2-trifluoromethoxy-benzoic acid

: 1138328-15-0
(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml4002612

Reference yield:

: 1138331-68-6
tert-butyl 4-(1-((3-(trifluoromethyl)phenyl)thio)ethyl)piperidine-1-carboxylate

: 1138328-15-0
(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; Oxone / methanol; water / 0.83 h / 20 °C / pH 3 / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water / 3 h / Reflux

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; Oxone; sodium hexamethyldisilazane; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml4002612

Reference yield:

: 1032825-55-0
tert-butyl 4-(1-((methylsulfonyl)oxy)ethyl)piperidine-1-carboxylate

: 1138328-15-0
(4-(methylsulfonyl)-2-(trifluoromethoxy)phenyl)(4-(2-((3-(trifluoromethyl)phenyl)sulfonyl)propan-2-yl)piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 50 °C / Inert atmosphere

2.1: potassium carbonate; Oxone / methanol; water / 0.83 h / 20 °C / pH 3 / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water / 3 h / Reflux

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; Oxone; sodium hexamethyldisilazane; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml4002612