6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

Base Information

Chemical Name:6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide
CAS No.:123441-84-9
Molecular Formula:C₂₆H₃₅N₃O₅
Molecular Weight:469.581
Hs Code.:

Synonyms:6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

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Chemical Property of 6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

Chemical Property:

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Technology Process of 6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

There total 5 articles about 6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2389-45-9
Boc-Lys(Z)-OH

: 100-46-9
benzylamine

: 123441-84-9
6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 13.5h;
DOI:10.1002/anie.201303999

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 123441-84-9
6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; copper (II) carbonate hydroxide / water / 2 h / 80 - 90 °C

1.2: 12 h / 25 °C

1.3: 24 h / 25 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 12 h / 0 °C

3.1: O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 5 h / 25 °C

With hydrogenchloride; copper (II) carbonate hydroxide; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.2174/092986610791306661

Reference yield:

: 56-87-1,3506-25-0
L-lysine

: 123441-84-9
6-(N-benzyloxycarbonyl)amino-2-(N-tert-butoxycarbonylamino)-N-benzylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; copper (II) carbonate hydroxide / water / 2 h / 80 - 90 °C

1.2: 12 h / 25 °C

1.3: 24 h / 25 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 12 h / 0 °C

3.1: O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 5 h / 25 °C

With hydrogenchloride; copper (II) carbonate hydroxide; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.2174/092986610791306661