(2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

Base Information

Chemical Name:(2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan
CAS No.:765923-94-2
Molecular Formula:C₃₃H₅₃NO₅Si₂
Molecular Weight:599.959
Hs Code.:

Synonyms:(2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

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Chemical Property of (2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

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Technology Process of (2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

There total 1 articles about (2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 765923-83-9
(S)-1-[(R)-2-(tert-butyldiphenylsilanyloxymethyl)tetrahydrofuran-(R)-3-yl]-4-methyl-(S)-2-nitropentan-1-ol

: 765923-94-2
(2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2004.06.060

Reference yield:

: 765923-94-2
(2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

: (S)-1-{(S)-(tert-Butyl-dimethyl-silanyloxy)-[(2R,3R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-methyl}-3-methyl-butylamine

Guidance literature:: With dihydrogen hexachloroplatinate; nickel; In methanol; under 3800.26 Torr;
DOI:10.1016/j.tet.2004.06.060

Reference yield:

: 765923-94-2
(2R,3R)-3-[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-2-nitro-pentyl]-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan

: 765923-84-0
((S)-1-{(S)-(tert-butyldimethylsilanyloxy)-[(R)-2-(tert-butyldiphenylsilanyloxymethyl)tetrahydrofuran-(R)-3-yl]methyl}-3-methylbutyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂PtCl₆; Raney Ni / methanol / 3800.26 Torr

2: 199 mg / Et₃N / tetrahydrofuran / 5 h

With dihydrogen hexachloroplatinate; nickel; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2004.06.060