2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline

Base Information

• Chemical Name: 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline
• CAS No.: 203320-55-2
• Molecular Formula: C₂₈H₂₄NOP
• Molecular Weight: 421.478
• Mol file: 203320-55-2.mol

Synonyms:2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline

Chemical Property of 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline

There total 3 articles about 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(2-fluoro-phenyl)-4-methyl-5-phenyl-4,5-dihydro-oxazole + potassium diphenylphosphine (15475-27-1,4346-39-8) → 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline (203320-55-2)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1080/10426500600781367

Reference yield:

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline (203320-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PPh₃; CCl₄ / acetonitrile / 2.5 h / 0 °C

1.2: NEt₃ / acetonitrile; CCl₄ / 1 h / 20 °C

1.3: 76 percent / PPh₃; CCl₄ / acetonitrile / 1 h / 20 °C

2.1: 86 percent / tetrahydrofuran / 0 °C

With tetrachloromethane; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1080/10426500600781367

Reference yield:

o-fluoro-benzoic acid (445-29-4) → 2-[2'-(diphenylphosphino)phenyl]-4-methyl-5-phenyloxazoline (203320-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PPh₃; CCl₄ / acetonitrile / 2.5 h / 0 °C

1.2: NEt₃ / acetonitrile; CCl₄ / 1 h / 20 °C

1.3: 76 percent / PPh₃; CCl₄ / acetonitrile / 1 h / 20 °C

2.1: 86 percent / tetrahydrofuran / 0 °C

With tetrachloromethane; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1080/10426500600781367

upstream raw materials:

potassium diphenylphosphine

(1R,2S)-norephedrine

o-fluoro-benzoic acid