4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide

Base Information

• Chemical Name: 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide
• CAS No.: 1260095-63-3
• Molecular Formula: C₅₄H₅₆N₄O₉
• Molecular Weight: 905.06

Synonyms:4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide

Chemical Property of 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide

Chemical Property:

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Technology Process of 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide

There total 3 articles about 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-amino-N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide (1260095-59-7) + 3,4-diphenylmethylenedioxyprotocatechuic acid (5693-25-4) → 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide (1260095-63-3)

Guidance literature:

3,4-diphenylmethylenedioxyprotocatechuic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

4-amino-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/ja106076h

Reference yield:

9H-fluoren-9-ylmethyl 1,7-bis(3-methoxymethylphenylamino)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-1,7-dioxoheptan-4-ylcarbamate (1260095-55-3) → 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide (1260095-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperidine / N,N-dimethyl-formamide / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 48 h / 20 °C

With piperidine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/ja106076h

Reference yield:

N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-4-nitroheptanediamide (1260095-57-5) → 4-(2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamido)-N1,N7-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide (1260095-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / ethanol / 12 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 48 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja106076h

upstream raw materials:

9H-fluoren-9-ylmethyl 1,7-bis(3-methoxymethylphenylamino)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-1,7-dioxoheptan-4-ylcarbamate

N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)-4-nitroheptanediamide

4-amino-N₁,N₇-bis(3-methoxymethylphenyl)-4-(3-(3-methoxymethylphenylamino)-3-oxopropyl)heptanediamide

3,4-diphenylmethylenedioxyprotocatechuic acid

Downstream raw materials:

N₁,N₇-bis(3-bromomethylphenyl)-4-(3-(3-bromomethylphenylamino)-3-oxopropyl)-4-(3,4-dihydroxybenzamido)heptanediamide

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