7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Base Information

Chemical Name:7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid
CAS No.:121209-29-8
Molecular Formula:C₂₂H₃₀N₂O₅S₂
Molecular Weight:466.623
Hs Code.:

7-<N-<1(R)-(ethoxycarbonyl)-3-phenylpropyl>-(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Synonyms:7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

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Chemical Property of 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

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Technology Process of 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

There total 6 articles about 7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 121209-29-8
7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 6.8 g / SOCl₂ / 20 h / Heating

2: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating

3: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature

4: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature

5: 1.) N,N-disuccinimidyl carbonate, pyridine, 2.) NEt₃ / 1.) CH₃CN, RT, 2.) CH₃CN, H₂O, RT

With pyridine; sodium hydroxide; thionyl chloride; di(succinimido) carbonate; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; triethylamine; In methanol; acetic acid;
DOI:10.1021/jm00127a033

Reference yield:

: 1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid ethyl ester hydrobromide

: 121209-29-8
7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature

2: 1.) N,N-disuccinimidyl carbonate, pyridine, 2.) NEt₃ / 1.) CH₃CN, RT, 2.) CH₃CN, H₂O, RT

With pyridine; sodium hydroxide; di(succinimido) carbonate; triethylamine; In methanol;
DOI:10.1021/jm00127a033

Reference yield:

: 83507-89-5
N-<(phenylmethoxy)carbonyl>-4-oxo-(S)-proline ethyl ester

: 121209-29-8
7--(S)-alanyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating

2: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature

3: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature

4: 1.) N,N-disuccinimidyl carbonate, pyridine, 2.) NEt₃ / 1.) CH₃CN, RT, 2.) CH₃CN, H₂O, RT

With pyridine; sodium hydroxide; di(succinimido) carbonate; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; triethylamine; In methanol; acetic acid;
DOI:10.1021/jm00127a033